Investigation of chemical exchange at intermediate exchange rates using a combination of chemical exchange saturation transfer (CEST) and spin-locking methods (CESTrho)
نویسندگان
چکیده
منابع مشابه
Study of chemical exchange in the intermediate exchange regime: a comparison of spin-locking and CEST techniques
Introduction: Recently, an indirect MRI detection of hydroxyl protons of small metabolites via the water signal was reported [1]. Selective off-resonance irradiation attenuates the water signal via chemical exchange saturation transfer (CEST) between hydroxyl and water protons. It was found that the magnetisation transfer (MT) asymmetry ratio (MTRasym) depends nonlinearly on hydroxyl-group conc...
متن کاملAnalytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
متن کاملSpin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons.
Chemical exchange saturation transfer (CEST) and spin-locking (SL) experiments were both able to probe the exchange process between protons of nonequivalent chemical environments. To compare the characteristics of the CEST and SL approaches in the study of chemical exchange effects, we performed CEST and SL experiments at varied pH and concentrated metabolite phantoms with exchangeable amide, a...
متن کاملMolecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI.
The two glucose analogs 2-deoxy-D-glucose (2-DG) and 2-fluoro-2-deoxy-D-glucose (FDG) are preferentially taken up by cancer cells, undergo phosphorylation and accumulate in the cells. Owing to their exchangeable protons on their hydroxyl residues they exhibit significant chemical exchange saturation transfer (CEST) effect in MRI. Here we report CEST-MRI on mice bearing orthotopic mammary tumors...
متن کاملOn the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T.
Chemical exchange saturation transfer (CEST) provides an indirect means to detect exchangeable protons within tissues through their effects on the water signal. Previous studies have suggested that amide proton transfer (APT) imaging, a specific form of CEST, detects endogenous amide protons with a resonance frequency offset 3.5 ppm downfield from water, and thus may be sensitive to variations ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2011
ISSN: 0740-3194
DOI: 10.1002/mrm.23213